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The Lewis Lab
peterlewislab.bsky.social
did:plc:2kirbxvnvj7rvtpaft5q3oyu
By contrast, removing the SUZ12 NBD yields an RNA-poor PRC2 that spreads H3K27me3 broadly in the genome, creating a massive low-level methylation background that decoys PRC1 away from its canonical targets- a global shift in mark abundance that doesn’t happen in the BRG1 setting.
2025-08-13T23:04:44.235Z