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DeBerardinis Lab at UT Southwestern Medical Center
rjdlab.bsky.social
did:plc:jco3skohm5obtzrgtgjczwzv
10/In studying why this happens, Wen discovered profound overexpression of MYC in the mutants, and high levels of H3K4 di- and trimethylation in MYC regulatory regions. These marks are associated with active gene expression, and their removal by KDM5 histone demethylases is blocked by L-2HG.
2025-04-20T20:48:54.083Z